Abstract:Following the informatization construction continues to advance in the medical field, in order to improve health care quality, and to use medical resources effectively, medical information sharing requirements become increasingly strong. Semantic heterogeneity is a major problem facing medical information resources sharing, this paper proposes the use of domain ontology integration of distributed heterogeneous database resources, describes the construction of medical domain ontology and design of application system for the realization of regional health information sharing provides an effective way.