Building energy-saving control is a multi-objective optimization problem considering the comfort demand. However, for the new buildings lacking operation data, it is a real conundrum to control the Heating, Ventilation and Air-Conditioning (HVAC) system to achieve both comfort and energy-saving. Aiming at this problem, this study first builds the space model of new buildings and then carries out simulation of energy consumption on the model. On this basis, it puts forward a fuzzy control algorithm based on thermal comfort of personnel to determine the optimal operation interval. Therefore, longer days of thermal comfort are enabled under the condition of lower energy consumption, achieving the goal of both energy saving and comfort. The energy-saving control based on the thermal comfort of personnel can promote the green operation of HVAC systems in buildings.