To improve SARS-CoV-2 information emergency response capability in hospitals, an emergency response method based on information systems was proposed. Relying on computer technology, Internet technology, and 5G technology, it has constructed an online emergency treatment area, established a current limiting management platform for outpatient and emergency, and conducted remote consultation for COVID-19 patients. It has realized the application of the whole process of online consultation, online prescription, and drug delivery for patients with chronic diseases and special diseases, established remote consultation services for COVID-19 patients between institutions, adjusted outpatient number allocation algorithms, and reduced cross infection rate. Adopting the information system of emergency measures, it has achieved the hospital from online to offline complete coverage, enhanced the control effect of SARS-CoV-2.