In order to solve the problems of test and simulation verification in the development of UAV system, this study designs an integrative test and simulation system based on PowerPC hardware platform and VxWorks software platform. The system is based on the simulation computer. Considering the two functional requirements of integrative test and simulation, the hardware and software of the system are designed. This paper expounds the working principle and design idea of the system from four aspects: the overall development scheme, the hardware design and implementation, the system communication protocol, and the software design and implementation. Finally, different application environments are built to test and verify the system, and the data analysis proves the practicability of the system, which will effectively improve the efficiency of research and development of UAV flight control system.