Aiming at the problems of small space and low complexity of low-dimensional chaotic system and single DNA encryption scheme, a color image encryption algorithm based on multi-chaotic mapping and DNA is proposed. Firstly, Arnold transform is used to scramble the position of each component of the image. Logistic-sine chaotic map is used to generate random matrices of the same size as the plaintext image and block them. Then DNA rule operation is performed. The operation mode is determined dynamically by the chaotic sequence generated by Chen hyperchaotic system. The simulation results show that the algorithm has good encryption and recovery effect, can effectively resist various statistical attacks and differential attacks, and has good security, anti-noise, complex and high encryption performance.