With its rapid development, WeChat has become an important platform for interpersonal communication, and occupies a unique position in the social network information dissemination. Based on the epidemic model, WeChat information propagation has established. The influence of model parameters and information sources on the scope and characteristics of WeChat information propagation is analyzed in multi-scenario with experimental data. Model simulation results and characteristics of propagation of WeChat have a very anastomotic match, which shows the WeChat information dissemination effect is important to control the use of WeChat.