With the rapid development of mobile terminal technology, wireless communication network technology and the universal application of geo-spatial information in all walks of life, the application mode that combines LBS with mobile GIS has become a hot research topic, and it opens up a market with unlimited potential. This paper discusses the basic concept of mobile GIS based on location services and the system architecture of Android development platform and the architecture of mobile GIS based on LBS. On the basis of this, a mobile GIS system based on Android platform is designed. The system has been improved on the basis of traditional mobile GIS, which overcomes the shortcomings of lack of social interaction in traditional mobile GIS, it not only can realize accurate real-time positioning and query trajectory, but also can share real-time location with friends and track the trajectory of many people at the same time. It can be used for real-time monitoring of the old elderly, children and other vulnerable groups, but also for employees, vehicle management scheduling.