Based on the project of “design and implementation of internet of things and GIS software platform”, we design a museum collection intelligent management system based RFID and GIS, in view of business process for museum collections management. Through the management of museum indoor map and recorded location of cultural relics in the registration and inspection of them, the system achieves the goal of realizing the online map visualization of cultural relics. And the system also can use RFID technology to realize the real-time location of inspectors and assess the inspection work of the inspectors. Combined with these two technologies, the system implements functions of auto-collect and real-time transmission of collection information and achieves the goal of unified and efficient management of the museum collections. Compared to the conventional way of collection management, this system improves the efficiency and convenience of collection information collection, and realizes the real-time dynamic intelligent management of the collection.