In the current communications technology, MIMO has a significant technological advantage. MIMO communication system applies multiple transmit antennas and multiple receive antennas. And it makes full use of space resources to improve the quality of communication and to enhance channel capacity under the condition of no increasing spectrum resource and the power of the transmission. However, the offset of the time and frequency will influence the performance of communication system largely. The Zynq-7000 is a new generation of programmable system on chip, which includes the core of ARM processor and integrated FPGA to provide a well software radio development environment. This paper presents a MIMO communication system on the Zynq-7000 platform with an algorithm of time and frequency synchronization and the processing of the implementation. The system tests demonstrate that the algorithm promotes the performance of the communication system.