To improve the informatization level of high-speed railway infrastructure safety monitoring and realize the real-time warning of overproof monitoring data, this paper studies and realizes high-speed railway infrastructure safety monitoring management system. This paper completes image vectorization and attribute data input by using ArcScan. System database of Oracle 11g is used and spatial database based on ArcSDE is constructed within it, then map service is published via ArcGIS Server. Based on B/S architecture, system in this paper realizes the real-time communication between the server and browser, and the functions of GIS module by calling of the ArcGIS API for JavaScript, realizing the real-time warning of overproof monitoring data. Application shows that the system improves the imformatization level of high-speed railway infrastructure safety monitoring, and its practicality is high.