Human Resources become the most important strategic resources of University Development. Human Resource Management System (HRMS) in university is an integrative information system. In base of the theory of the Whole Life Cycle, the HRMS considers the staff as the main business. This paper divides the Whole Life Cycle into five different stages: before into university, come into university, in the university, leave university/retirement, pass away. At the same time, this paper analyses the data flow and the association between each stage process, realizes the dynamic management of personnel data, and puts forward a UC matrix to meet the needs of data sharing among different departments.