With the QR code technology being widely applied in electronic ticketing, bank checks, E-commerce and other fields, many safety problems have emerged, such as information leakage and data tampering. Based on Visual Studio 2008 c platform, the method with Rijndael random variable and random keys secondary Rijndael encryption protection is proposed using Rijndael encryption and SHA512 digital signature technology. This paper presents a novel design of information security before generating QR code. The encryption principle, algorithm and implementation, safety performance of the proposed method are discussed. Also corresponding testing and analysis are provided to verify the feasibility of the proposed algorithm. Results have proved that the information safety performance of QR code is greatly increased with the encryption algorithm, the efficient management and the multiple- protection to a key. This just causes a smaller increase in the content of the encryption data than those of the raw data.