For the convenience that the patient is not restricted to time and space to get the health care knowledge, this paper uses the technology based on J2ME and J2EE, designs and develops a mobile medical consultation system. The mobile client of the system can realize the functions of login for registered users, query for drugs, symptoms and disease, deployment for comments and announcement. The WEB server can manage the information of user, medical, disease, announcements and comment. The system can realize the maximization sharing of medical knowledge, and to a certain extent, alleviate the pressure of the difficult medical treatment and nervous medical resources. Experimental results show that the system has the advantages of simple operation, strong portability, fast loading speed and less resource-intensive, and thus reaching the design requirements.