The paper studies on the optimal management of South China Normal University E-mail system. The current campus E-mail system is introduced, including system and network deployment, reception and dispatch processes. The operation and security problems of E-mail system are analyzed, including the school mailbox and the mailbox communication abroad poor, signaling mechanism exists security vulnerabilities. Finally, from the aspects of registered reverse domain name and optimization of signaling mechanism, the overall optimization scheme and implementation steps of mail system are given. Studies have shown that optimal management of South China Normal University E-mail system, not only solved the problem of system operation and safety, enhance the user experience, but also brought convenience to administrators of maintenance and management. It has a certain reference value in college E-mail system management applications.