To solve the traditional pharmacy health care high pressure, low efficiency and other issues, an automated prescription mixing system based on boil-free granule of Traditional Chinese Medicine of total components is designed and implemented with modular design. It obtains from prescription get, prescription analysis to prescription process automatically. This paper proposes a general method for medicine depot organizations, studies different scheduling algorithms of bottle using and compares their effects to mixing efficiency. Practice shows that the system is easy to operate and human-friendly, and has high accuracy, efficiency, and practical value.