A dynamic optimization model is proposed based on different response time. The model considers the features of multi-retrieval depots, multi-resource and multi-objective emergency scheduling problem, and combines with the constraints of response time led by the sensitive areas of oil spill. With the earliest emergency rescue time and the fewest number of retrieval depots as the optimization goal, the perfect point method and structuring elimination assemble are used to get the optimal scheduling scheme according to different response time slots. Finally, a numerical example is given to verify the feasibility of the proposed scheduling method.