In order to improve the utilization of medical resources further, this paper improves the quality of medical service, which can reduce the medical cost and risk. To construct a classification treatment model more perfect and reasonable, it is need to build a regional medical information sharing and collaborative services platform which uses the medical service institutions as the main body. The medical resources and information are sharing as the goal. Integrate the generic technology and medical service techniques, and implement the sharing and the collaborative about the regional medical information, resources and the service. In this paper, according to the demand of the regional medical information sharing and collaboration service requirements, we propose the overall architecture of the platform, and we also put forward solutions to propose the key issues which are the main index of patients, the document sharing crossing regional, the clinical document's construction, the term service, data acquisition and transmission, the hospital pre service, document storage and so on.