With the advancement of informationization in our society, the Information system of function and performance required more and more. System performance optimization was dependent on information system analysis and design, system development, system operation and maintenance, system updates four stages. During information system design and development of numerous enterprises, the system function was concerned but the system optimization was few concerned. The system optimization only was focused on system operation and maintenance stage. This causes the system to be "fire-fighting" optimization, only suppress the symptoms not the illness or cause the system to optimize the cost was huge, and even the system cannot be optimized, and the system was forced to retired early. This article on how to optimize the performance of the whole life cycle of information system were discussed, some strategies were put forward to optimize the performance of each stage, and combining the practical application in detail.