Many applications are not fault-tolerant and require a reliable service which only TCP can provide. In 6LoWPAN network, because of the restrictions of node hardware and the underlying communication protocol, the compression of TCP packet must be done. However, there is no related standard currently. The TCP header compression Scheme named LOWPAN_TCP_HC for 6LoWPAN network based on the characteristics of 6LoWPAN networks and the study of existing TCP header compression scheme had been proposed in this paper. The experimental results show that LOWPAN_TCH_HC can effectively compress TCP header, reduce the sensor node energy consumption and extend the node's working time.