Thinking about the situation of small and medium enterprises(SMEs) with the character of small scale, low ability to take risk, short of talent, this paper introduces thought and technology into SME cooperation. Technologies related Web2.0 and current situation of SMEs are presented and the applying mode in enterprises collaboration is put forward. It researched technology for self-organization and standard for evaluation, and Witkey mode for mission outsourcing, and SNS for collaborating between enterprises. Web2.0 will do a lot to solve the problems faced SMEs.