According to the present problems of bad performance of anti-interference and difficult maintenance exited in our mine combined switch, a design scheme of new comprehensive protection controller of dual-circuits mine combined switch based on PLC is proposed in this paper. This comprehensive protection controller uses the Germany Siemens s7-200 PLC as central control unit, though the hardware design and software programming can achieve protections of short circuit, overload, broken phase, over voltage, earth leakage interlock. Meanwhile, human-machine interface uses WeinviewMT6070iH all Chinese LCD touch screen to display, concise intuitively and easy operation. The result of the experiment shows that the controller of all kinds of protective functions can work accurately and quickly, ensures the whole equipment work safety, stability and anti-interference ability.