Medical image enhancement is an important section during the medical image processing. Through analysising shortcomings of ROF(Rudin, Osher and Fatemi) model and Wavelet de-noising, first, we decomposed the image into three parts which are structure, details as well as noise, and kept the structure afterwards. Next, by considering on the non-Gaussian character of the wavelet coefficients, we applied Wavelet de-noising to the details as well as noise part. Then we obtained the details. Finally, we plused the structure and the details. According to the result, the higher PSNR and higher EPI have witnessed the better performance of the algorithm.