A mobile RFID reader based on Zigbee wireless technology is designed in this paper. This paper shows the block diagram of the mobile reader, and detail the external circuit of the RF chip CC2420, and card reader integrated chip MF RC522, and main control chip MSP430F1611, as well as the reader's software architecture. The reader collects tag data, and sends the data to the server automatically through the ZigBee network. Mobile RFID reader reduces the RFID system network cabling, saves the cost, and is used more convenientiy and flexibleiy.