At the age of globalization, as the increase in the personnel mobility rate, the transmission modes and speed of epidemic diseases go far beyond those in the past. The basic principles and methods of building the personnel monitoring and management system based on the blockchain technology were expounded. When a major infectious disease attacks, the people from the epidemic area and confirmed or suspected patients are monitored in real time. The system can inquire into the history of personnel mobility, find close contacts, and search for the sources of infection, which can support isolation measures for epidemic prevention and control.