By using multiple micro controller computers and personal computer, this paper realizes campus express goods management system, which uses the RFID (Radio Frequency Identification) technology to substitute the traditional barcode technology, improving the efficiency of data acquisition. This system has the advantages of fast response, strong real-time and simple operation, and it provides a more efficient solution for package in-out warehouse, inventory, and package position guidance. Experimental results show that RFID technique can improve the efficiency of package storage, to achieve rapid inventory and guide courier parcel position. It can solve the problems caused by frequent changes of goods locations, simplify work flow and reduce labor costs.