The benefits and shortcomings of XML configuration and zero configuration of the Spring Framework is compared from several aspects. How to use two configurations flexible in the actual development is summarized to improve the efficiency of project development. Firstly, XML configuration and zero configuration of the Spring Framework is introduced. Secondly, how to implement dependency injection of the Spring Framework is illustrated through XML configuration and zero configuration. Then, the relative advantages of XML configuration to zero-configuration is analyzed from bone architecture and design aspects of the Spring framework. Practice results show that the zero configuration should be used during the development of practical application. And late in the development, when the function of the project is completed, zero configuration should be converted to XML configuration, disable zero configuration. Thus, the efficiency of project development will be improved significantly.