For better, faster collaborative innovation of "production, learning and research", this paper proposed a method, six-helix structure of cloud computing platform for collaborative innovation based on cloud computing, triple helix and collaborative innovation. It has designed five collaborative architecture and some functional modules. This platform can not only integrate various technological resources, human resources, service resources, but also can make "political, corporate, school, research and gold" to get the latest information, demand and supply in Autonomous, interactive environment, and cross-sectoral collaboration, interdisciplinary collaboration, collaborative innovation finally. For solid research exchanges, promote universities, research institutes and research achievements in industry, accelerate the construction and upgrading of technology of SMEs is important.