Currently mobile operating systems including Android, iOS, Window Phone, Symbian, BlackBerry OS, etc., application software is independent of each other. The different system is not compatible with a large difference. As a result, the multi-platform application development cycle is long and difficult to transplant. In this paper, the current mobile application development solutions and the latest development techniques are analyzed. This article is focused on PhoneGap application development framework, characteristics and principles of analysis. Based on the analysis, a cross-platform mobile application solution is presented. And a practice is explored by using the presented solution.