Being lacking in effective means of monitoring the status of domestic drug sales enterprise, combined with the actual work demands of Food and Drug Administration of Yichun City, a Drug Administration Information System is designed. B/S and C/S structure are adopted and Microsoft Visual Basic .net platform is used. Real-time monitoring and supervision of drug sales are realized, and administration efficiency is improved. Drug administration paperless office is realized. The sudden vital events will be quickly dealt with. Management of enterprise is regulated. The practical problems in drug sales and drug supervision are effectively resolved. There is practical significance of the promotion of the drug administration.