This paper designs a hierarchical operational decision-making support system based on Multi-Agent. The system is divided into decision-making, decision-support and data platform layer. It has functions like intelligence analysis, program evaluation, plan Deduction, and directly interacts with user through the general information processing platform. And the use of multi-agent technology such as collaborative mechanisms, drive mechanisms and knowledge-learning mechanism can ensure the system to respond fast and flexibly, to make correct decision in real time and to realize the intelligent human-machine combination.