Multi-energy systems provide a new solution to energy and environmental problems through the collaborative optimization of production, transmission and consumption of different forms of energy, such as electricity, heat and gas. Energy Hub (EH) is the coupling link of a multi-energy system, and its configuration scheme is crucial to the optimal operation of the multi-energy system. In this context, a scheme for optimal operation and configuration of EHs with different forms of energy, such as electricity, heat and natural gas, is proposed, taking into account the CO₂ emission. On the basis of considering CO₂ emission, a multi-objective optimization problem is raised, which is solved by Genetic Algorithm (GA) overall with the aim of maximizing social benefits and minimizing CO₂ emission. Finally, the effectiveness of the proposed method is verified through the analysis of different configuration examples. This study can provide theoretical and technical support for the construction and operation of EHs.