With the wide application of message-oriented middleware in large-scale distributed systems, its security should be paid more attention. This study analyzes the security risks in the traditional shared response queue application of ActiveMQ, and it proposes a message-oriented middleware application mode based on random response queue. In this application mode, the response queue name is randomly generated by user client. Only the client and server know the random name. The random queue is very hidden, so it can ensure security application of the message queue. The basic framework, operation flow and safety analysis of the application mode are given. The operation performance is analyzed by theoretical calculation. The conclusion shows that the security application mode does not affect the operation performance of the system.