Aiming at the problem of insufficient understanding of human body structure in the process of character animation and painting, and the advantages of virtual reality technology in education, a simulation system of artistic human anatomy drawing based on Forge cloud is proposed. According to the proportion of the human body structure, the system uses the block surface line model to complete the construction and visualization process of the human model. According to the law of animation motion, human motion simulation is realized by combining skeleton animation with three-dimensional motion capture. Human-computer interaction is completed through Forge cloud platform and Three.js. Finally, the manga module and Forge cloud module are communicated bidirectionally to complete the manga character posture simulation. Tests show that the system has a high degree of simulation and ease of use. It provides an environment for digital learning and mobile learning. It helps learners to understand the anatomical structure of human body deeply and grasp the modeling method of cartoon characters correctly.