With the continuous development of e-commerce, the volume of campus express business has grown rapidly. The traditional express pick-up mode has low efficiency in entering and leaving the warehouse, and the labor cost in the logistics link is high. Based on this, this study proposes a communication management system based on RFID and ZigBee, which uses ZigBee for networking and RFID technology to realize automatic management of express delivery. RFID tags are attached to the packaging of each cargo, and fixed readers are set on the shelf of the station to obtain information such as the location of the goods. The user scans the express label on the exit gate channel and the QR code on the mobile phone to match, to complete the self-pickup. It improves the efficiency of the express delivery.