In order to solve the problem of massive orders scheduling in the cloud logistics environment, this paper proposes a scheduling algorithm based on orders clustering. Firstly, aiming at the single center multi vehicle scheduling problem, an optimal scheduling algorithm based on the single parent genetic algorithm is proposed. On this foundation, considering the location of the city distribution centers, the vehicles and the distribution points, the type and the demand of goods, an order clustering model based on distribution center is built by using the ant colony algorithm.