Based on the defects of traditional information center construction, this paper presents an implementation of virtual optimization vSphere architecture scheme based on informationcenter. Compared with other embodiments of virtualization, the scheme is mainly optimized from two aspects of reliability and storage I/O performance. The scheme optimizes the system reliability from three aspects of the server, network and storage equipment. It analyzes the influence factors of storage device's I/O performance. These factors are separately whether to use the multipath input and output, write-back cache write strategy, I/O disk block size and service performance etc. Finally, through the test of the whole system, we proved the advantages of the scheme.