With our national strategy implementation involving large civil aircraft, AFDX endpoint card based on FPGA is proposed, which is specific to AFDX backbone network of large aircraft avionics system. Based on the thought of HW/SW co-design, the programme designs a new type of AFDX endpoint card with PCIE or SOPC interface. AFDX endpoint card based on FPGA can be directly applied in such platforms as large military transport aircraft, helicopters, fighter jets, airport ground maintenance system and so on and can enhance safety and reliability of military computer. What's more, development process will be accelerated and the cost will be lowed by offering related standards and specifications for electronic equipments of different kinds of weapon platforms.