Prison is responsible for the social harmony and preventing and reducing crime. It’s self-evident to realize the importance of strengthening the intelligent and informationbased management of prison. Considering the development of the prison using modern management, this paper designs a prisoner location information system based on zigbee technology and makes CC2530/2431 from TI as a core. It states system network topological structure and structure schematic drawing and basic working principles, gives out the hardware circuit and mobile terminal software flow chart, designs prevent removing loop circuit for the mobile terminal emphatically. The system can realize personnel location, low power alarm and anti-demolition etc. Function.