Logistics distribution center is the key of modern logistics chain hub. To reduce the distribution center exercises in human, material and waste of time, this paper researches and designs a rfid-enabled AGV system. The system of the RFID system and AGV automatic control system integrate. This system can pass AGV mobile to achieve cargo information extraction, handling, storage, goods in place, which can replace traditional artificial homework. It greatly improves the logistics distribution center operation efficiency and accuracy.