The internet of things has been paid more and more attention for its huge application prospect by the governmnet, academe and industry all over the world. “Intelligent Logistics” has attracted widespread concern. Based on the research on the concept, technology system, structure and basic principle, the paper proposes a highly intelligent design solution of warehouse management system applying the technology of the Internet of Things. It focuses on analyzing the working process, overall structure and functional module of the system, which follows by the further analysis of the realization of RFID system, wireless sensor monitoring network and operation system. The system solves the problems, like the low efficiency of logistics information process and inaccurate inventory check, which exist wide in the traditional warehouse management, and it is fast, convenient, accurate, efficient and highly automated, while further effort has to be made to lower cost and improve security.