The safety management of construction enterprises has not only relation to the development of construction industry, but also has a strong impact on harmoniousness and progress of society. This paper constructed the evaluation index system from manager perspective, and explained the relationship of evaluation index briefly. Then, this paper applied the principle component analysis which carries on the pretreatment to the input data of nerve network, and withdrew essential ingredient as the input of the network. Subsequently, genetic algorithm was applied to improve the convergence ratio. Finally, the analysis results was given out based on the example of Tianjin city. The results indicate that the model is not only more fair but also reasonable. It improved the learning efficiency of the neural network model.