Due to the problems of production facilities and productivity effect, traditonal fermentation technology of rice wine is known to be inefficient. In this paper, we address the problems with a new automatic control system. Its hardware platform consists of PLCs, intelligent instruments, and industrial control computers. Its application is programed based on Labview. In the production process of rice wine, it has high reliability and real-time and can monitor the various parameters effectively. Productive results show that it can meet the demand of rice wine fermentation.