Currently, the wired mode in household audio system is complex and difficult to change, whereas it costs too much to use Bluetooth to transmit aundio data. Based on these issues, we design a low-cost, low-power wireless audio system which uses TI's MSP430F1611 as the master chip to control the USB interface chip CH375 to read mp3 audio files inside a U disk, and transmits the data streams through ZigBee network to the sub-node, then decode and output the signal by audio decoder chip VS1003. It innovatively uses embedded USB-HOST and ZigBee technology in domestic sound system and achieves the wireless transmission of audio data.