How to solve the problem with humanization design and how to meet the constraints of more efficient arrangement system are the difficult points of educational administration. According to some colleges' course arrangement problem, this paper puts forward a college course arrangement method based on space model. First, we compare and analyze the advantages and disadvantages of the present ways of course arrangements. Then, it combines the college's requirement of actual course arrangement, builds up the space model and restrict model of course arrangement so as to decrease the complexity of course arrangement. At last, it optimizes the course arrangement method based on genetic algorithm and puts forward a solution project of course arrangement problem. The experimental results show that this course arrangement system has solved this college's course arrangement problem better and also provide experience for other similar problems.