A water cleaning control system based on the reconfigurable program of statistical process control (SPC) is proposed to connect a water cleaning machine to an industrial network and realize intelligent automatic control. The system uses parameters and component characteristics of water cleaning equipment to construct the control protocol of the equipment and formulates an instruction judgment module according to the protocol instruction. In addition, it designs a process control module through SPC theory. The control protocol makes the cleaning program of the system capable of reconfiguration and networking. The judgment module ensures the security of reconstructed instructions. The process control module makes the cleaning process of the system able to dynamically adjust cleaned components. These functions enable the equipment to realize intelligent automatic control. Through the test, the average cleaning times of the system are reduced by 15%, and the utilization rate of water cleaning solutions is increased by about 5% compared with the original system. Furthermore, three functions have been expanded, which improves the utilization rate and intelligence level of the equipment, and the requirements of energy and water saving, multiple purposes, and networking are finally satisfied.