A performance evaluation system is developed for medical insurance departments to objectively supervise the medicare-designated pharmacy. According to the standard set of the medicare-designated pharmacy, Vue.js and Django Rest Framework are selected to build an evaluation system in Node.js and REST styles. The system has evaluated the performance of 881 medicare-designated pharmacies in Shanghai. It builds a database of Shanghai’s pharmacy performance and issues a customized assessment report. The system makes the management and assessment of the medicare-designated pharmacy more efficient, reducing the supervision cycle from 4 weeks to 1 week and administrative manpower by 128 person-months/year. As an information-based tool, it can support pharmacy managers, expert assessment teams and administrative supervisors and help medical insurance services better benefit people.