A data association model and a mathematical motion simulation model are built for the real-time motion process of ground moving targets in ground support of airports. The simulation program is improved on the basis of the GIS geographic data, graphics device interface (GDI+), multithreading technology, and concurrent synchronization mechanisms. In the simulation process, the improved A* algorithm is used to determine the best driving path of moving targets at airports, and the moving states of the targets are monitored in real time using data visualization technology. Finally, the repetition method is employed to carry out multiple tests for statistical analysis of the simulations. The simulation model has been applied to many fields, such as the deduction of the ground support process of airports, airport emergency plan verification, and flight transportation decision-making. It is of great significance to improve the ability of airports to support flight transit.