The intelligent traffic application under the single camera scene has been well developed, but the cross-regional research is still in its infancy. This study proposes a cross-camera scene stitching method based on camera calibration. Firstly, the mapping relationship between the physical information in the sub-world coordinate system and the two-dimensional image in the two camera scenes is established by vanishing point calibration. Secondly, the projection transformation between the cameras is completed by the common feature information between the two sub-world coordinate systems. The road scene stitching is completed by the proposed inverse projection idea and the translation vector relationship. The experimental results show that the proposed method can achieve road scene splicing and cross-region road physical measurement, which lays a foundation for relevant practical application research.